U.S. doctors’ group endorses event-based PrEP

AMSTERDAM — For the first time, a U.S.-based doctors group has endorsed event-based PrEP use. AIDSMap.com reported that the International Antiviral Society-USA (IAS-USA) made the recommendation during the International AIDS Conference in Amsterdam last month. In this case, event-based means PrEP is given on demand instead of a regular daily dose. According to AIDSMap, IAS-USA recommends event-driven PrEP as an alternative for cisgender men who have sex with men, following the protocol used in the IPERGAY study: i.e. a double dose (two pills) of TDF/FTC between 24 and two hours in advance of anticipated sex, then, if sex happens, one pill the following day and one the day after – or to be continued daily until two days after the last sex. The website reported that the group warns against event-driven dosing for women (as vaginal tissue concentrations only reach 10% of rectal concentrations), for all transgender people, and for people at risk through drug injection (for lack of evidence).

Study shows no HIV transmission with undetectable partners

AMSTERDAM — Researchers at the 22nd International AIDS Conference confirmed Tuesday that the chance of any HIV-positive person with an undetectable viral load transmitting the virus to a sexual partner is scientifically equivalent to zero. Aidsmap reported that the results were presented during the opening press conference for the event. From Aidsmap:
Final results from the PARTNER study were presented this morning at a press conference on the opening day of AIDS 2018. Results originally announced in 2014 from the first phase, PARTNER 1, already indicated that “Undetectable equals Untransmittable” (U=U). However, the statistical certainty of this result was not quite as convincing in the case of gay men, or for anal sex, as it was for vaginal sex. Results from PARTNER 2, the second phase, which only recruited gay couples, were presented today.